MECHANISM OF ACTION
Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels(VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium channels belong to the “low-voltage activated group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channel serves pacemaking functions in both central neurons and cardiac nodal cells and supporting calcium signalling in secretory cells and vascular smooth muscle. They may also be involvedin the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
DRUG DRUG INTERACTION
• VALPROATES: Valproates can either decrease or increase the level of ethosuccimide and also with valproates it had a greater protective index than either drug alone
It may elevate serum phenytoin level
• AMPHETAMINE: The therapeutic efficacy of Ethosuccimide can be decreased when used in combination with Amphetamine.
• APREPITAN: The serum concentration of Ethosuccimide can be increased when it is combined with Aprepitant.
SIDE EFFECTS
Common Side Effect
• Dizziness
• Headache
• Nausea
• Stomach Upset Or Pain
• Vomiting
Severe Side Effect
• Rash
• Hives
• Itching
• Difficulty in Breathing
• Pain in chest or tightness
• Confusion
• Dark urine
• Fever
• Joint pain
• Swelling or sever Tenderness
• Persistent loss of appetite
• Swollen gland in the neck or armpit
THERAPEUTIC USES
• It is an anticonvulsant so it is used for Controlling certain type of seizures
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