KETOCONAZOLE-Anti fungal drug

PHARMACOLOGY OF KETOCONAZOLE

INTRODUCTION

Ketoconazole is a synthetic imidazole antifungal drug used primarily to treat fungal infection. This is less toxic and generally more effective triazole antifungal agent.

MECHANISM OF ACTION

Ketoconazole interacts with 14 alpha demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol .This results in inhibition of ergosterol synthesis and increased fungal cellular permeability.

PHARMACOLOGICAL ACTIONS

USES

1.Anti fungal

2.Systemic antifungal

3.Anti androgenic and antiglucocorticoid

4.Veterinary

SIDE EFFECTS

1. Black tarry stools

2. Bleeding gums

3. Blurred vision

4. Chest pain

5. Chills

6. Confusion

7. Cough

8. Dark urine

9. Fast heartbeat

Reference- Tripathi KD "Essential of medical pharmacology" 7th edition, page no- 26,787,792,793,845