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Friday, February 16, 2018

KETANSERIN-5HT and its Antagonist

PHARMACOLOGY OF KETANSERIN
MECHANISM OF ACTION
Ketanserin is a serotonin antagonist with a high affinity for peripheral serotonin-2 receptors and thus inhibits serotonin-induced vasoconstriction, bronchoconstriction and platelet aggregation.

USES
1.Anti-hypertension
2.In cardiac surgery

SIDE EFFECTS
1.Ventricular tachycardia
2.Ventricular arrhythmias
3.Drowsiness
4.Visual disturbances
5.Fatigue
6.Dry mouth
7.Sedation.

Reference- Tripathi KD "Essential of medical pharmacology" 7th edition, page no- 174-175
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