PHARMACOLOGICAL ACTION :
It is an oligonucleotide that blocks translation of viral m-RNA by binding to the complementary sequence of the mRNA transcribed from the template segment of key
CMV gene UL123,which encodes the CMV protein IE2.
SIDE EFFECTS :
Abnormal vision, eye inflammation, abdominal pain , fever ,headache , rash , sepsis , vomitting .
CONTRAINDICATIONS
It is not to be taken along with pregnancy because it causes hypersensitivity reactions.
THERAPEUTIC USES :
It is used in the treatment of CYTMEGALOVIRUS RETINITIS in immunocompromised patients .
REFERENCE- Tripathi K.D. "Essentials of Medical Pharmacology", 7th Edition, page no- 801
It is an oligonucleotide that blocks translation of viral m-RNA by binding to the complementary sequence of the mRNA transcribed from the template segment of key
CMV gene UL123,which encodes the CMV protein IE2.
SIDE EFFECTS :
Abnormal vision, eye inflammation, abdominal pain , fever ,headache , rash , sepsis , vomitting .
CONTRAINDICATIONS
It is not to be taken along with pregnancy because it causes hypersensitivity reactions.
THERAPEUTIC USES :
It is used in the treatment of CYTMEGALOVIRUS RETINITIS in immunocompromised patients .
REFERENCE- Tripathi K.D. "Essentials of Medical Pharmacology", 7th Edition, page no- 801
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