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Thursday, February 15, 2018

Fludarabine- Anticancer drug and its pharmacology

MECHANISM OF ACTION 

Fludarabin phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate 2-fluoro –ara ATP this metabolite appears to act by inhibiting DNA polymerase alpha ,ribo nucleotide reductase and DNA primase thus, inhibiting DNA synthesis.

THERAPEUTIC USES

  • Used in treatment of chronic lymphocytic leukemia 
  • It is a chemotherapy drug used in treatment of hematlogical malignancy

SIDE EFFECTS
  • Anemia
  • Lymphopenia
  • Thrombocytopenia 
  • Neutropenia

DRUG DRUG INTERACTION

  1. Fludarabin+ pentostatin=risk of adverse effect is increased
  2. Fludarabin+natalizumab =risk of adverse effect is increased

REFERENCE:-Tripathi K D"Essential of medical pharmacology",7th edition ,page no-858,864
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