Etophylline-drugs for cough and bronchial asthma and its pharmacology

MECHANISM OF ACTION

It relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. It competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Also binds to adenosine A2B receptor and blocks adenosine medialed bronchoconstriction.

DRUG-DRUG INTERACTION 

1) ABIRATERONE: the serum concentration of etophylline can be increased when it is combined with abiraterone.

2) ACEBUTOLO: The risk or severity of adverse effect can be increase when acebutolo is combined with etophylline

3) ACETAMINOPHEN: the serum concentration of drug can be increased when it is combined with etophylline

THERAPEUTIC USES

• Treat lung disease: asthma and COPD 

REFERENCE:-Tripathi K D"Essential of medical pharmacology",7th edition ,page no-227