Etdolac-Non steroidal Anti inflammatory and antipyretic analgesic and its pharmacology

MECHANISM OF ACTION

The anti-inflammatory effects of etodolac result from inhibition of the enzyme cyooxyenase (COX). This decrease the synthesis of peripheral prostaglandins involved in mediating inflammation. Etodolac binds to upper portion of the COX enzyme active site and prevents its substrate, arachidonic acid from entering the active site.

DRUG DRUG INTERACTION

• ABACIXIMAB: Etodolac may increase the anticoagulant activities of abacixmab.

• ACETYLSALICYLIC ACID: The risk or severity of adverse effects can be increased.

• ALISKIREN: Etodolac may decrease the antihypertensive activities of Aliskiren.

SIDE EFFECTS

• Sneezing

• Runny or stuffy nose

• Wheezing

• Swelling of face, lips tongue or throata

• Nausea

• Vomiting

• Indigestion

• Itching

• Rash

• headache

THERAPEUTIC USES

• mild fever

• pain

• inflammation

• arteoarthritis

• rheumatoid arthritis

REFERENCE:-Tripathi K D"Essential of medical pharmacology",7th edition ,page no-192, 204-205