INTRODUCTION:-
* This compound belongs to the class of organic compounds known as ergotamines, dihydroergotamines and derivatives.
* These are structurally characterized by a benzyl substituent attached to the piperazine ring of the ergopeptine backbone.
MECHANISM OF ACTION:-
* Activation of 5-HT1D located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache .
* 2) Activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
PHARMACOKINETICS:
* HALF LIFE :- 9 hours.
* PROTEIN BINDING :- 93%
* Volume of distribution :- 800 L
* ACETOPHENAZINE +DHE= adverse effects can be increased.
* APREPITANA+DHE= The serum concentration of DHE can be increased.
* BOCEPRAVIL+ DHE= The serum concentration of DHE can be increased.
SIDE EFFECTS:-
* Drowsiness
* Headache
* Nausea
* Vomiting
* Diarrhoea
* Flushing
* Dizziness
THERAPEUTICS USES:- It works by narrowing the blood vessels around the brain and affects blood flow patterns that are associated with certain types of headaches. injection is used to treat a migraine or cluster headache attack.
* This compound belongs to the class of organic compounds known as ergotamines, dihydroergotamines and derivatives.
* These are structurally characterized by a benzyl substituent attached to the piperazine ring of the ergopeptine backbone.
MECHANISM OF ACTION:-
* Activation of 5-HT1D located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache .
* 2) Activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
PHARMACOKINETICS:
* HALF LIFE :- 9 hours.
* PROTEIN BINDING :- 93%
* Volume of distribution :- 800 L
DRUG –DRUG INTERACTIONS-
* ACEPROMAZINE+ DHE= The risk of adverse effects can be increased .* ACETOPHENAZINE +DHE= adverse effects can be increased.
* APREPITANA+DHE= The serum concentration of DHE can be increased.
* BOCEPRAVIL+ DHE= The serum concentration of DHE can be increased.
SIDE EFFECTS:-
* Drowsiness
* Headache
* Nausea
* Vomiting
* Diarrhoea
* Flushing
* Dizziness
THERAPEUTICS USES:- It works by narrowing the blood vessels around the brain and affects blood flow patterns that are associated with certain types of headaches. injection is used to treat a migraine or cluster headache attack.
REFERENCE:-Tripathi K D; "Essential of medical pharmacology";7th edition ;page no-140,175,176,178
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