INTRODUCTION-This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring.
MECHANISM OF ACTION-
The precise mode of action of thiabendazole on the parasite is unknown, but it most likely inhibits the helminth-specific enzyme fumarate reductase.
METABOLISM- Hepatic.
ROUTE OF ELIMINATION-Through urine.
DRUG-DRUG INTERACTIONS-
* THIABENDAZOLE+ ABIRATERONE=The serum concentration of Thiabendazole can be increased .
* THIABENDAZOLE+AMINOPHYLLINE=The metabolism of Aminophylline can be decreased .
* THIABENDAZOLE+CITALOPRAM=The metabolism of Thiabendazole can be decreased .
SIDE EFFECTS-
It has CNS side effects and hepato toxic N potential.
THERAPEUTIC USES-
* For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis
* It is a fungicide and parasiticide.
* It is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning.
* It is vermicidal and vermifugal.
MECHANISM OF ACTION-
The precise mode of action of thiabendazole on the parasite is unknown, but it most likely inhibits the helminth-specific enzyme fumarate reductase.
METABOLISM- Hepatic.
ROUTE OF ELIMINATION-Through urine.
DRUG-DRUG INTERACTIONS-
* THIABENDAZOLE+ ABIRATERONE=The serum concentration of Thiabendazole can be increased .
* THIABENDAZOLE+AMINOPHYLLINE=The metabolism of Aminophylline can be decreased .
* THIABENDAZOLE+CITALOPRAM=The metabolism of Thiabendazole can be decreased .
SIDE EFFECTS-
It has CNS side effects and hepato toxic N potential.
THERAPEUTIC USES-
* For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis
* It is a fungicide and parasiticide.
* It is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning.
* It is vermicidal and vermifugal.
REFERENCE :-Tripathi K D,"Essential of medical pharmacology";7th edition ;page no -851,852
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