PHARMACOLOGY OF ISOTRETINOIN
MECHANISM OF ACTION
Isotretinoin reduces the production of sebum and shrinks the sebaceous glands. It stabilizes keratinisation and prevents comedones from forming. It also reduces inflammation in moderate-severe inflammatory acne. It alters DNA transcription.
It is used to prevent severe nodular acne, harlequin-type icthyosis, and skin cancer.
5. Increased liver enzymes
6. Decrease hdl cholesterol
7. Dry nose
10. Increased serum cholesterol
DRUG DRUG INTERACTION
1. Isotrtinoin+ alcohol = unpleasant side effects such as fast heartbeats, warmth, redness under skin.
2. Isotretinoin + tetracycline = increase pressure in brain leads to permanent vision loss