Wednesday, February 14, 2018

Dihydroergotoxine-antiadrenergic drugs and its pharmacology.

                     
DESCRIPTION :
It is more potent alpha blocker .this compound belongs to the class of organic compound known as ergopeptines.these are ergoline derivative that contain a tripeptide .


PHARMACODYNAMICS :
 It may increase cerebral metabolism and blood flow .The role of this medication in the therapy of dementia is controversial .A recent  controlled study in patient with Alzheimer disease found that there was no advantage to use of ergoloid mesylates compared to placebo,further study is needed to determine the risk -benifit profile of it in the treatment of dementia.




MECHANISM OF ACTION :

 It act centrally ,decreasing vascular tone & slowing the heart rate & act peripherally to block alpha receptor . One another possible mechanism is the effect of it on neuronal cell metabolism .Resulting in improved oxygen uptake and cerebral metabolism ,thereby normalising depressed neuro-transmitter level .

PHARMACOKINETIC PROPERTY :

Absorption : Absorbed from GIT .Eliminated by 1st pass metabolism .
Protein binding :98-99%
 Metabolism :Hepatic
 Halflife : 3.5 hr

ADVERSE EFFECT:
                    Dyspnea
                    Hypotention
                    rapid weak pulse
                    Delirium
                    Nausea ,vomiting
                    bradycardia

DRUG -DRUG INTERACTION :
             Acepromazine + Dihydroergotoxin =Risk of adverse effect can be increased .
             Acetophenazine + Dihydroergotoxin = risk of adverse effect can be increased .
            Apripitant + Dihydroergotoxin =  serum concentration of ergotoxin can be increased.                             Boceprevir + Dihydroergotoxin = Serum concentration of ergotoxin may be increased.




THERAPEUTIC USES  :     

              Pheochromocytoma
              Hypertention
              benign hypertrophy of prostat
              congestive heart failure
               Pheripheral vascular diseases

REFERENCE:-Tripathi K D"Essential of medical pharmacology",7th edition ,page no. 140,141,175,176,489,491.

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