INTRODUCTION:-This compound belongs to the class of organic compounds known as amphetamines and derivatives. These are organic compounds containing or derived from 1-phenylpropan-2-amine.
MECHANISM OF ACTION :-
Dexfenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin reuptake. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates
PHARMACOKINETICS :-
* PROTEIN BINDING :- 36%
HALF LIFE :- 17-20 hrs
SIDE EFFECTS :-
* Respiratory failure
* Cardiac arrest leading to death.
* Headache
* Asthenia
* Abdominal pain
* Chills
* Accidental injury
* Infection
* Flu syndrome
* Back pain
* Fever
* Allergic reactions
DRUG-DRUG INTERACTION :-
* RITONAVIR +DEXFENFLURAMINE = Dexfenfluramine oral will increase the level or effect of ritonavir oral by altering drug metabolism.
THERAPEUTIC USES :-
* For the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet.
* it reduces appetite by increasing the amount of extracellular serotonin in the brain.
REFERENCES: Tripathi K.D,"Essentials of medical pharmacology", Edition 7th page no.-134, 137
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