IVABRADINE-Anti- Anginal drug

PHARMACOLOGY OF IVABRADINE

MECHANISM OF ACTION

Ivabradine lowers heart rate by selectively inhibiting if channels (funny channels )  in the heart in a concentration dependent manner without affecting any other cardiac ionic channels . Ivabradine binds by entering and attaching to a site on the channels pore from the intracellular side and disrupts. If current flows, which prolongs diastolic depolarization, lowering heart rate. The if currents are located in the sinoatrial node and are the homes of all cardiac pacemaker activity. Ivabradine therefore lowers the pacemaker firing rate, consequently lowering heart rate and reducing myocardial oxygen demand. This allows for improved oxygen supply and therefore mitigation of ischemia, allowing for a higher exercise capacity and reduction in angina episodes

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USES

1. Angina pectoris

2. Heart failure

SIDE EFFECTS

1. Blurred vision

2. Fainting

3. Shortness of breath

4. Pounding in ears

5. Seeing flashes of light

DRUG DRUG INTERACTION

1. IVABRADINE + LOPRESSOR = both can slow the heart rate , cause conduction problems, irregular heart rhythm.

Reference- Tripathi KD "Essential of medical pharmacology" 7th edition, page no- 540,554