DESCRIPTION:
Hemichloinium also known as hemicholine, is a drug which
block the reuptake of choline by high affinity choline transporter at the
presynapse.
MECHANISM OF ACTION:
Acetylcholine is synthesized from choline and a donated
acetyl group from acetyl co-A ,by the action of choline transferase.
Hemicholinium (HC3) blocks choline uptake (rate limiting
step in Ach synthesis) and depletes Ach.
PHARMACOLOGY:
Drug that inhibit the
transport of neurotransmitters into axon terminal or into storage vesicles
within terminal s. For many transmitters , uptake determines the time course of
transmitter action so inhibiting uptake prolongs the activity of the
transmitter.Blocking uptake may deplete
available transmitter stores. Many clinically important drugs are uptake
inhibitors although the indirect reaction of the brain rather than the acute
block of uptake itself is often responsible for the therapeutics effects.
THERAPEUTIC USES:
Hemicholinium is commonly used as a research tool in animal
and in vitro experiments.
DRUG-DRUG INTERACTION:
Atropine + Hemicholinium (HC3) = Inhibit the action of
atropine.
REFERENCE
Tripathi KD, Essential of Medical Pharmacology, 7th edition,
Jaypee Brothers Medical Publisher (P) LTD. Page No: 100
No comments:
Post a Comment