DESCRIPTION:
Halothane is a general anaesthetic. It is the only inhalational anaesthetic containing bromine.
MECHANISM OF ACTION:
Halothane acts on multiple ion channels, which ultimately depresses nerve conduction ,breathing, cardiac contractility, which causes general anaesthesia & immobilizing effects have been attributed to its binding to potassium channels in cholinergic neurons.
When halothane is binds to NMDA and calcium channels then it causing hyperpolarisations.
PHARMACOLOGY:
It is a general inhalational anaesthetic used for induction and maintenance of general anaesthesia.
It reduces the blood pressure and frequently decreases respiration.
It induces muscles relaxation and reduces pains sensitivity by altering tissue excitability.
THERAPEUTIC USE:
Use as inhalation anaesthetic.
ADVERSE EFFECTS:
• Liver injury
• Hepatitis ( it occurs due to inflammation in liver)
• Malignant hyperthermia
DRUG-DRUG INTERACTION:
• Fesophenytoin, Phenytoin + Halothane = the serum concentration of fosphenytoin & phenytoin can be increased when it is combined with halothane.
REFERENCE
Tripathi KD, Essential of Medical Pharmacology, 7th edition, Jaypee Brothers Medical Publisher (P) LTD. Page No: 372
Halothane is a general anaesthetic. It is the only inhalational anaesthetic containing bromine.
MECHANISM OF ACTION:
Halothane acts on multiple ion channels, which ultimately depresses nerve conduction ,breathing, cardiac contractility, which causes general anaesthesia & immobilizing effects have been attributed to its binding to potassium channels in cholinergic neurons.
When halothane is binds to NMDA and calcium channels then it causing hyperpolarisations.
PHARMACOLOGY:
It is a general inhalational anaesthetic used for induction and maintenance of general anaesthesia.
It reduces the blood pressure and frequently decreases respiration.
It induces muscles relaxation and reduces pains sensitivity by altering tissue excitability.
THERAPEUTIC USE:
Use as inhalation anaesthetic.
ADVERSE EFFECTS:
• Liver injury
• Hepatitis ( it occurs due to inflammation in liver)
• Malignant hyperthermia
DRUG-DRUG INTERACTION:
• Fesophenytoin, Phenytoin + Halothane = the serum concentration of fosphenytoin & phenytoin can be increased when it is combined with halothane.
REFERENCE
Tripathi KD, Essential of Medical Pharmacology, 7th edition, Jaypee Brothers Medical Publisher (P) LTD. Page No: 372
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