EXENATIDE THERAPEUTIC USES,SIDE EFFECTS AND DRUG DRUG INTERACTION

EXENATIDE

                                                                          

FORMULA   : C18H282N50060S

MOLAR MASS  :4186.6gm/mol

THERAPEUTIC USES : Used as adjunctive therapy to improve glycemic control in patients with                                                type 2 diabetes mellitus.

MECHANISM OF ACTION: Exenatide is a functional analog of the human incretin Glucagon-Like Peptide-1 (GLP-1). Incretins enhance glucose-dependent insulin secretion and exhibit other antihyperglycemic actions following their release into the circulation from the gut. The GLP-1 system increases insulin secretion only in the presence of elevated plasma glucose levels, avoiding inappropriately high insulin levels during fasting. The drug also moderates peak serum glucagon levels during hyperglycemic periods following meals, but does not interfere with glucagon release in response to hypoglycemia. Secondary effects of drug administration reduces the rate of gastric emptying and decreases food intake, mitigating the potential severity of hyperglycemic events after meals.

SIDE EFFECTS  :  Jittering

                                 Sour stomach

                                 Belching 

                                 Diarrhea

                                 Heartburn

                                 Dizziness

                                 Headache

DRUG DRUG INTERACTION :  METAHEXAMIDE+ EXENATIDE : Exenatide may increase                                                                the hypoglycemic activities of Metahexamide