Saturday, February 17, 2018

Lopinavir-antiviral drug


Mechanism of action
It inhibits the HIV viral  protease enzyme.this prevents cleaveage of gag-pol polyprotein and, herefore, improper viral assembly results.

Drug-drug interaction
Lopinavir+alogliptin =  efficacy of alogliptin decreases
Lopinavir+aminodaron = lopinavir increases QT prolonging activities of aminodarone
Lopinavir+barnidipine = serum concentration of barnidipine increases
Lopinavir+bepridil = metabolism of bepridil decreases

Pharmacological action
It is highly bound to plasma protein.

Side effects 
Abdominal pain

Therapeutic uses
It is used in HIV treatment.
It is given in fixed dose with ritonavir for treatment of HIV/AIDS

Reference- Tripathi KD "Essential of medical pharmacology" 7th edition, page no- 798,809,811,814

No comments:

Post a Comment