NIFEDIPINE:
MECHANISM OF ACTION-
• It’s a prototype DHP with a rapid onset of action with short duration.
• It’s a calcium channel blocker.
• In body tissue cells concentration of calcium outside is 10000 folds higher than the calcium present inside of the cell and they’re embedded in some cell membrane called calcium channels.
• When these channels receive some signals they get open resulting into the entering of calcium inside the cell.
• Calcium channel blockers narrows the opening of these membranes thus reduce the amount of calcium inside the cell.
• Nifedipine have nonspecific activity towards voltage-dependent calcium channels.
REFERENCE:Tripathi K.D., “Essentials of Medical Pharmacology”, Jaypee brothers medical publishers, Seventh edition, New Delhi, page no.562-563.
MECHANISM OF ACTION-
• It’s a prototype DHP with a rapid onset of action with short duration.
• It’s a calcium channel blocker.
• In body tissue cells concentration of calcium outside is 10000 folds higher than the calcium present inside of the cell and they’re embedded in some cell membrane called calcium channels.
• When these channels receive some signals they get open resulting into the entering of calcium inside the cell.
• Calcium channel blockers narrows the opening of these membranes thus reduce the amount of calcium inside the cell.
• Nifedipine have nonspecific activity towards voltage-dependent calcium channels.
REFERENCE:Tripathi K.D., “Essentials of Medical Pharmacology”, Jaypee brothers medical publishers, Seventh edition, New Delhi, page no.562-563.
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