Mechanism of action of sulfasalazine:-
The
mode of action of Sulfasalazine or its metabolites, 5-aminosalicylic acid
(5-ASA) and sulfapyridine (SP), is still under investigation, but may be
related to the anti-inflammatory and/or immunomodulatory properties that have
been observed in animal and in vitro models, to its affinity for connective
tissue, and/or to the relatively high concentration it reaches in serous
fluids, the liver and intestinal walls, as demonstrated in autoradiographic
studies in animals. In ulcerative colitis, clinical studies utilizing rectal
administration of Sulfasalazine, SP and 5-ASA have indicated that the major
therapeutic action may reside in the 5-ASA moiety. The relative contribution of
the parent drug and the major metabolites in rheumatoid arthritis is unknown.
Reference:-
Tripathi k.d.,"Essentials of Pharmacology",published by
jaypee brother publication ,new dehli,seventh edition,p.no:-211
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