DESCRIPTION
Hydroxyzine is a first-generation antihistamine of the diphenylmethane and piperazine class.
PHARMACOKINETICS
1. Rapidly absorbed from the gastrointestinal tract.
2. Protein binding is 93%.
3. Half life is 20 to 25 hours.
THERAPEUTIC USES
1. It is used as a sedative to treat anxiety and tension.
2. It is also used together with other medications given for anesthesia.
3. It may also be used to control nausea and vomiting.
4. It is also used to treat allergic skin reactions such as hives or contact dermatitis.
SIDE EFFECTS
1. Drowsiness/somnolence
2. Headache Dizziness, attention disturbance
3. Tremor, convulsions
4. Dry mouth
5. Constipation, nausea
DRUG-DRUG INTERACTIONS
1. epressant) activities of Alfentanil.
2. Hydroxyzine + Amphetamine = Decrease the sedative activities of Hydroxyzine.
3. Hydroxyzine + Aripiprazole = The serum concentration of Aripiprazole is increased.
4. Hydroxyzine + Aclidinium = Increase in the anticholinergic activities of Hydroxyzine.
Hydroxyzine is a first-generation antihistamine of the diphenylmethane and piperazine class.
PHARMACOKINETICS
1. Rapidly absorbed from the gastrointestinal tract.
2. Protein binding is 93%.
3. Half life is 20 to 25 hours.
THERAPEUTIC USES
1. It is used as a sedative to treat anxiety and tension.
2. It is also used together with other medications given for anesthesia.
3. It may also be used to control nausea and vomiting.
4. It is also used to treat allergic skin reactions such as hives or contact dermatitis.
SIDE EFFECTS
1. Drowsiness/somnolence
2. Headache Dizziness, attention disturbance
3. Tremor, convulsions
4. Dry mouth
5. Constipation, nausea
DRUG-DRUG INTERACTIONS
1. epressant) activities of Alfentanil.
2. Hydroxyzine + Amphetamine = Decrease the sedative activities of Hydroxyzine.
3. Hydroxyzine + Aripiprazole = The serum concentration of Aripiprazole is increased.
4. Hydroxyzine + Aclidinium = Increase in the anticholinergic activities of Hydroxyzine.
5. Hydroxyzine + Alfentanil = Increase in the central nervous system depressant
REFERENCE- Tripathi K.D. "Essentials of Medical Pharmacology", 7th Edition, page no- 164, 165, 467
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