DICLOFENAC SODIUM-
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID).
This medicine works by reducing substances in the body that cause pain and inflammation.
Pharmacology:
Indication - For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Pharmacodynamics - Diclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis
Absorption- Completely absorbed from the gastrointestinal tract.
Volume of distribution- 1.3 L/kg
Protein binding -More than 99%
Half life- 2 hours
Clearance- oral cl=622 mL/min
renal cl <1 mL/min
Drug Drug interactions:
Diclofenac + Adefovir= cause kidney problems, and combining it with other medications that can also affect the kidney such as diclofenac may increase that risk.
Diclofenac + Cidofovir= cause kidney damage, and combining it with other medications that can also affect the kidney such as diclofenac may increase that risk
Diclofenac +Enoxaparin= Combining these medications can increase the risk of bleeding complications
Methotrexate +Diclofenac= blood level and kideny diseases.
Therapeutic Uses:
>Diclofenac is used to relieve pain, swelling (inflammation), and joint stiffness caused by arthritis. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID).
>If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain.
>Diclofenac is used to treat mild to moderate pain, or signs and symptoms of osteoarthritis or rheumatoid arthritis.
>Diclofenac powder (Cambia) is used to treat a migraine headache attack.
Side effects:
> Stomach pain, indigestion, heartburn, wind, nausea (feeling sick) or vomiting (being sick).
> Any sign of bleeding in the stomach or intestine, for example, when emptying your bowels, blood in vomit or black, tarry faeces.
> Allergic reactions which can include skin rash, itching, bruising, painful red areas, peeling or blistering.
> Wheezing or shortness of breath (bronchospasm).
> Swollen face, lips, hands or fingers.
> Yellowing of your skin or the whites of your eyes.
> A persistent sore throat or high temperature.
> An unexpected change in the amount of urine produced and/or its appearance.
> You bruise more easily than usual or have frequent sore throats or infections.
REFERENCE:-Tripathi K D"Essential of medical pharmacology",7th edition ,page no-204,208
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