Dibucaine-
A local anesthetic of the amide type now generally used for surface anesthesia.
It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia.
Pharmacology:
Indication -For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.
Pharmacodynamics -Dibucaine is an amide-type local anesthetic, similar to lidocaine.
Absorption-In general, ionized forms (salts) of local anesthetics are not readily absorbed through intact skin. However, both nonionized (bases) and ionized forms of local anesthetics are readily absorbed through traumatized or abraded skin into the systemic circulation.
Drug Drug interactions:
Lidocaine+dibucaine= can cause a condition called methemoglobinemia that reduces the oxygen-carrying capacity of the blood to different organs.
Therapeutic Uses:
>Relieving pain and itching due to sunburns, minor burns, cuts, scratches, insect bites, stings, or hemorrhoids.
>Dibucaine Ointment is a topical anesthetic. It produces numbness for a short period of time by stopping nerves from sending pain impulses to the brain.
Side effects:
> Chest pain
> fast or irregular heartbeat
> tightness in the chest
> unusual warmth or flushing of skin
> Diarrhea
> eye irritation
> nausea
> skin irritation
> vomiting
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