Diazoxide-
A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies.
It lacks diuretic effect, apparently because it lacks a sulfonamide group.
Pharmacology:
Indication -Used parentally to treat hypertensive emergencies. Also used to treat hypoglycemia secondary to insulinoma.
Absorption-Readily absorbed following oral administration.
Protein binding-Very high (more than 90%) to serum proteins.
Metabolism-Hepatic.
Route of elimination-Proglycem is extensively bound (more than 90%) to serum proteins, and is excreted in the kidneys.
Half life- 28 ±8.3 hours in normal adults.
Drug drug interactions:
Acebutolol+Diazoxide= Diazoxide may increase the hypotensive activities of Acebutolol.
Atenolol+Diazoxide= Diazoxide may increase the hypotensive activities of Atenolol.
Benazepril+Diazoxide= Diazoxide may increase the hypotensive activities of Benazepril.
Betaxolol+diazoxide= Diazoxide may increase the hypotensive activities of Betaxolol.
Therapeutic Uses:
> used to treat very low blood sugar levels (hypoglycemia).
>drug works by preventing insulin release from the pancreas, helping to return the blood sugar to normal levels.
Side effects:
> pounding heartbeats or fluttering in your chest
> swelling in your hands, ankles, or feet
> fine hair growth on the face, arms, and back (especially in women or children)
> nausea, vomiting, stomach pain, loss of appetite
> diarrhea, constipation
> decreased sense of taste
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