DIAZEPAM-
Diazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peens).
It affects chemicals in the brain that may be unbalanced in people with anxiety.
Pharmacology:
Absorption- Essentially complete, with a bioavailability of 93%.
Protein binding- 98.5%
Half life - Biphasic 1-2 days and 2-5 days, active metabolites with long half lives.
Drug Drug interactions:
1. diazepam+Aprepitant= The serum concentration of Diazepam can be increased when it is combined with Aprepitant.
2. diazepam+Bexarotene= The serum concentration of Diazepam can be decreased when it is combined with Bexarotene.
3. diazepam+Bortezomib= The metabolism of Diazepam can be decreased when combined with Bortezomib.
4. diazepam+Clozapine= The risk or severity of adverse effects can be increased when Diazepam is combined with Clozapine.
Food interactions:-
> Avoid alcohol.
> Avoid excessive quantities of coffee or tea (caffeine).
> Avoid taking with grapefruit or grapefruit juice as grapefruit can significantly increase serum levels of this product.
>Take with food.
Therapeutic Uses:
>used to treat anxiety, alcohol withdrawal, and seizures.
>used to relieve muscle spasms and to provide sedation before medical procedures.
Side effects:
> confusion, hallucinations, unusual thoughts or behavior;
> depressed mood, thoughts of suicide or hurting yourself;
> hyperactivity, agitation, aggression, hostility;
> new or worsening seizures;
> weak or shallow breathing, a feeling like you might pass out;
> muscle twitching, tremor;
> loss of bladder control; or
> little or no urinating.
Common diazepam side effects may include:
> drowsiness;
> tired feeling;
> muscle weakness
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