Saturday, February 17, 2018

Losartan-antiangiotensin drug


Mechanism of action
It blocks uptake of uric acid into cells, using a specific inhibitor of urate transporter 1.

Therapeutic uses
Hypertension treatment
Reduction of renal diseases
Type 2 diabetes

Side effects
Upper respiratory infections
Back pain
Low BP

Pharmacological action
It is a selective competitive angiotensin 2 receptor type 1 antagonist. Its administration results in decrease in total peripheral resistance  and cardiac venous return .  plasma rennin activity  also increases.

Drug drug interaction
Losartan+aliskiren = increase hyperglycemia activity of losartan
Losartan+butabarbitol = increase hypotensive activity of losartan

Reference- Tripathi KD "Essential of medical pharmacology" 7th edition, page no- 498,506,558,561

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