Mechanism of action
It blocks uptake of uric acid into cells, using a specific inhibitor of urate transporter 1.
Reduction of renal diseases
Type 2 diabetes
Upper respiratory infections
It is a selective competitive angiotensin 2 receptor type 1 antagonist. Its administration results in decrease in total peripheral resistance and cardiac venous return . plasma rennin activity also increases.
Drug drug interaction
Losartan+aliskiren = increase hyperglycemia activity of losartan
Losartan+butabarbitol = increase hypotensive activity of losartan
Reference- Tripathi KD "Essential of medical pharmacology" 7th edition, page no- 498,506,558,561