Friday, February 16, 2018

Lanreotide-Anterior Pituitary Hormone


Lanreotide (INN) is a medication used in the management of acromegaly and symptoms caused by neuroendocrine tumors, most notably carcinoid syndrome. It is a long-acting analogue of somatostatin, like octreotide. Its sequence is H-D-2Nal-Cys(1)-Tyr-D-Trp-Lys-Val-Cys(1)-Thr-NH2.

Pharmacological Action
Lanreotide is a somatostatin analog approved for treatment of neuroendocrine tumours and acromegaly. Lanreotide exhibits antisecretory effects through cAMP suppression, and activation of ion currents such as K+ and Ca2+ which leads to hyperpolarization of the membrane and inhibition of Ca2+ mediated depolarization. Furthermore, through direct and indirect mechanisms, Lanreotide has potent antiproliferative effects.

Used in treatment of acromegaly.
It shows activity against non-endocrine tumors.

Side Effect
Gastrointestinal disturbance such as-
Gallstone formation

Drug Drug Interaction
Codeine + Lanreotide = metabolism of codeine can be decreased.
Bretyliun + Lanreotide = bretyliun can increase the bradycardial activity of lanreotide.

Reference- Tripathi KD "Essential of medical pharmacology" 7th edition, page no- 238

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