DESCRIPTION
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.
THERAPEUTIC USES
Ibuprofen is used to reduce fever and treat pain or inflammation caused by many conditions such as headache, toothache, back pain, arthritis, menstrual cramps, or minor injury.
SIDE EFFECTS
• Abdominal pain
• Acid or sour stomach
• Belching
• Bloating
• Cloudy urine
• Decrease in amount of urine
• Decrease in urine output or decrease in urine-concentrating ability
• Diarrhoea
• Difficulty having a bowel movement (stool)
• Excess air or gas in stomach or intestines
• Heartburn
• Indigestion
• Itching skin
• Pain or discomfort in chest, upper stomach, or throat
• Pale skin
• Passing gas
• Nausea
• Noisy, rattling breathing
• Rash with flat lesions or small raised lesions on the skin
• Swelling of face, fingers, hands, feet, lower legs, or ankles
• Troubled breathing at rest
• Troubled breathing with exertion
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Vomiting
DRUG-DRUG INTERACTIONS
1. Ibuprofen + Alteplase = Increase in the anticoagulant activities of Alteplase.
2. Ibuprofen + Amikacin = decrease the excretion rate of Amikacin which could result in a lower serum level and potentially a reduction in efficacy.
3. Ibuprofen + Apixaban = The risk or severity of adverse effects can be increased.
4. Ibuprofen + Drospirenone = Increase in the hyperkalemic activities of Drospirenone.
5. Ibuprofen + Eplerenone = Decrease in the antihypertensive activities of Eplerenone.
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.
THERAPEUTIC USES
Ibuprofen is used to reduce fever and treat pain or inflammation caused by many conditions such as headache, toothache, back pain, arthritis, menstrual cramps, or minor injury.
SIDE EFFECTS
• Abdominal pain
• Acid or sour stomach
• Belching
• Bloating
• Cloudy urine
• Decrease in amount of urine
• Decrease in urine output or decrease in urine-concentrating ability
• Diarrhoea
• Difficulty having a bowel movement (stool)
• Excess air or gas in stomach or intestines
• Heartburn
• Indigestion
• Itching skin
• Pain or discomfort in chest, upper stomach, or throat
• Pale skin
• Passing gas
• Nausea
• Noisy, rattling breathing
• Rash with flat lesions or small raised lesions on the skin
• Swelling of face, fingers, hands, feet, lower legs, or ankles
• Troubled breathing at rest
• Troubled breathing with exertion
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Vomiting
DRUG-DRUG INTERACTIONS
1. Ibuprofen + Alteplase = Increase in the anticoagulant activities of Alteplase.
2. Ibuprofen + Amikacin = decrease the excretion rate of Amikacin which could result in a lower serum level and potentially a reduction in efficacy.
3. Ibuprofen + Apixaban = The risk or severity of adverse effects can be increased.
4. Ibuprofen + Drospirenone = Increase in the hyperkalemic activities of Drospirenone.
5. Ibuprofen + Eplerenone = Decrease in the antihypertensive activities of Eplerenone.
REFERENCE- Tripathi K.D. "Essentials of Medical Pharmacology", 7th Edition, page no- 199, 200, 208, 209
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