MECHANISM OF ACTION
Ethambutol inhibits arabinosyl transferases which is involved in cell wall biosynthesis. By inhibiting this enzyme, the bacterial cell wall complex production is inhibited. This leads to an increase in cell wall permeability.
DRUG DRUG INTERACTION
• ALUMINUM HYDROXIDE: Aluminum hydroxide can cause a decrease in the absorption of Ethambutol resulting in a reduced serum concentration and potentially a decrease in efficacy.
SIDE EFFECTS
Common Side Effect
• Appetite loss
• Dizziness
• General Body Discomfort
• Headache
• Nausea
• Stomach Upset Or Pain
• Vomiting
Severe Side Effect
• Rash
• Hives
• Itching
• Difficulty in Breathing
• Pain in chest or tightness
• Confusion
• Dark urine
• Fever
• Joint pain
• Swelling or sever Tenderness
• Persistent loss of appetite
• Swollen gland in the neck or armpit
THERAPEUTIC USES
• Tuberculosis
• Bacterial infection
REFERENCE:-Tripathi K D"Essential of medical pharmacology",7th edition ,page no-765,766,769,774,776,779
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