Saturday, February 17, 2018

Loxapine- antiphyschotic drug


Mechanism of action
Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranuilization as calming effects and suppression of aggressive behavior.

Pharmacological action 
Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established, however, it is believed that by antagonising dopamine and serotonin receptors, there is a marked cortical inhibition which can manifest as tranquilization and suppression of aggression.
 Loxapine is a psychiatric medication (antipsychotic type) that works by helping to restore the balance of certain natural substances (such as dopamine) in the brain.

Therapeutic uses
Loxapine is used to treat certain mental/mood disorders (such as schizophrenia).
This medicine helps you to think more clearly, feel less nervous, and take part in everyday life. It can reduce aggression and the desire to hurt yourself/others.
It may also help to decrease hallucinations .

Side effects
Dry mouth
Weight gain
 Blurred vision
Muscle spasm

Drug drug interaction 
Loxapine + Amantadine = The therapeutic efficacy of Loxapine can be decreased when used in combination with Amantadine.
Loxapine + Amoxapine = The risk or severity of adverse effects can be increased when Amoxapine is combined with Loxapine.
Loxapine + Amitriptyline = The risk or severity of adverse effects can be increased when Amitriptyline is combined with Loxapine.

Reference- Tripathi KD "Essential of medical pharmacology" 7th edition, page no- 436,440,441

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