DESCRIPTION:
Guaiphenesin or Guaifenesin also glycerol guaiacolate . It is an expectorant drug sold over the counter.
Guaifenesin was first approved by the Food and Drug Administration (FDA) in 1952.
MECHANISM OF ACTION:
Guaifenesin is thought to act as an expectorant by increasing the volume and reducing the viscosity of secretion in the trachea and bronchi, i.e.:- flow of respiratory tract secretion allowing cilliary movement to carry the loosened secretion upward towards the pharynx. Thus it may increase the efficiency of the cough reflex and facilates removal the secretion. Guaifenesin has muscle relaxant and anticonvulsant properties and may be acting as an NMDA receptor antagonist.
PHARMACOLOGY:
It is metabolised by hydrolysis via CYP450.
Excretion: Urine
Half Life: 1 hour.
THERAPEUTIC USES:
• Used in treatment of cough, bronchits.
• Used as antitussive (expectorant)
ADVERSE EFFECTS:
• Dizziness (due to inner ear disturbance, infection, reduced blood flow due to blocked arteries)
• Headache
• Nausea , vomiting or stomach upset
• Swelling of face, lips, tongue or throat, Rashes.
DRUG –DRUG INTERACTION:
There are no drug interaction with guaifenesin, but in case of first trimester of pregnancy and an increased risk of hernia in the fetus.
REFERENCE:
Tripathi KD, Essential of Medical Pharmacology, 7th edition, Jaypee Brothers (P) LTD. Page No: 221
Guaiphenesin or Guaifenesin also glycerol guaiacolate . It is an expectorant drug sold over the counter.
Guaifenesin was first approved by the Food and Drug Administration (FDA) in 1952.
MECHANISM OF ACTION:
Guaifenesin is thought to act as an expectorant by increasing the volume and reducing the viscosity of secretion in the trachea and bronchi, i.e.:- flow of respiratory tract secretion allowing cilliary movement to carry the loosened secretion upward towards the pharynx. Thus it may increase the efficiency of the cough reflex and facilates removal the secretion. Guaifenesin has muscle relaxant and anticonvulsant properties and may be acting as an NMDA receptor antagonist.
PHARMACOLOGY:
It is metabolised by hydrolysis via CYP450.
Excretion: Urine
Half Life: 1 hour.
THERAPEUTIC USES:
• Used in treatment of cough, bronchits.
• Used as antitussive (expectorant)
ADVERSE EFFECTS:
• Dizziness (due to inner ear disturbance, infection, reduced blood flow due to blocked arteries)
• Headache
• Nausea , vomiting or stomach upset
• Swelling of face, lips, tongue or throat, Rashes.
DRUG –DRUG INTERACTION:
There are no drug interaction with guaifenesin, but in case of first trimester of pregnancy and an increased risk of hernia in the fetus.
REFERENCE:
Tripathi KD, Essential of Medical Pharmacology, 7th edition, Jaypee Brothers (P) LTD. Page No: 221
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