Mechanism of action
Binds to riboflavin hydrogenase, riboflavin
kinase, and riboflavin synthase. Riboflavin is the precursor of flavin mononucleotide
(FMN, riboflavin monophosphate) and flavin adenine dinucleotide (FAD). The antioxidant
activity of riboflavin is principally derived from its role as a precursor of FAD
and the role of this cofactor in the production of the antioxidant reduced glutathione.
Reduced glutathione is the cofactor of the selenium-containing glutathione peroxidases
among other things. The glutathione peroxidases are major antioxidant enzymes.
Reduced glutathione is generated by the FAD-containing enzyme glutathione reductase.
Reference: Tripathi K.D., "Essentials of Pharmacology", published by
jaypee brother publication, New Delhi, seventh edition, page no:-606, 913, 914.
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