Saturday, March 17, 2018


Mechanism of action
It is progestrin derivative exerts its action through nuclear progesterone receptors situated in female genital tract , breast ,CNS and pituitary.When the drug binds to progesterone receptors it undergoes dimerization and attaches to progesterone response element of target genes and regulates transcription through co-activators ;which ultimately leads to modification of protein synthesis. It  contributes to proper development and maintenanace of female sexual functions.
It prepare uterus for nidatioin amd maintenance of pregnancy.It prepare endometrial shedding decrease uterine motility and inhibits immunological rejection of foetus.

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