Mechanism of action
-Mupirocin(pseudomonic acid A, or bactroban)is an
isolated from Pseudomonas flourescens.
-Isoleucyl t-RNA synthatase is an enzyme which
promote conversion of isoleucine and t-RNA to isoleucyl t-RNA
-Mupirocin binds selectively and revesibly to
isoleucine t-RNA synthatase which results in inhibits of bacterial protein and
RNA synthesis.
Reference: Tripathi K.D.,
“Essentials of Medical Pharmacology”, Jaypee brothers medical publishers,
Seventh edition, New Delhi, page no. 759.
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