Thursday, March 22, 2018


Mechanism of action

-Mupirocin(pseudomonic acid A, or bactroban)is an isolated from Pseudomonas flourescens.
-Isoleucyl t-RNA synthatase is an enzyme which promote conversion of isoleucine and t-RNA to isoleucyl t-RNA
-Mupirocin binds selectively and revesibly to isoleucine t-RNA synthatase which results in inhibits of bacterial protein and RNA synthesis.

Reference: Tripathi K.D., “Essentials of Medical Pharmacology”, Jaypee brothers medical publishers, Seventh edition, New Delhi, page no. 759.

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