Thursday, March 22, 2018



•    It’s thiazide derivative.
•    In distal convoluted tubule, which is a part in the kidney, they inhibit the sodium-chloride symporter.
•    Blood is filtered into the lumen which is a open space of the tubule. Whatever remains in the tubule will travel to the bladder as urine and eventually be excreted.
•    Cells lining the tubule absorb necessary salts and excrete some of materials.
•    Tubule cells in the distal convoluted tubule possess the ATP-powered sodium-potassium antiporter or Na+/K+-ATPase which uses energy from ATP to transfer three sodium ions out from the blood vessels with simultaneously transferring potassium inside.
•    Metolazone inhibit the function of the sodium-chloride symporter by preventing sodium, chloride and water.So that they are excreted in urine not reabsorbed in blood stream.


REFERENCE:Tripathi K.D., “Essentials of Medical Pharmacology”, Jaypee brothers medical publishers, Seventh edition, New Delhi, page no.583.

No comments:

Post a Comment