Wednesday, March 21, 2018

Icatibant


Mechanism of action of Icatibant

Bradykinin is a peptide-based hormone that is formed locally in tissues, very often in response to a trauma. It increases vessel permeability, dilates blood vessels and causes smooth muscle cells to contract. Bradykinin plays an important role as the mediator of pain. Surplus bradykinin is responsible for the typical symptoms of inflammation, such as swelling, redness, overheating and pain. These symptoms are mediated by activation of bradykinin B2 receptors. Icatibant acts as a bradykinin inhibitor by blocking the binding of native bradykinin to the bradykinin B2 receptor.

Reference-
Tripathi K.D “Essentials of Medical Pharmacology", published by Jaypee brothers, New Delhi, 7th edition, page no. 511.

No comments:

Post a Comment