Mechanism of action of Icatibant
Bradykinin is a
peptide-based hormone that is formed locally in tissues, very often in response
to a trauma. It increases vessel permeability, dilates
blood vessels and causes smooth muscle cells to contract. Bradykinin plays an important role
as the mediator of pain. Surplus bradykinin is responsible for the typical symptoms of
inflammation, such as swelling, redness, overheating and pain. These symptoms are
mediated by activation of bradykinin B2 receptors. Icatibant acts as a
bradykinin inhibitor by blocking the binding of native bradykinin to the
bradykinin B2 receptor.
Reference-
Tripathi K.D “Essentials of Medical Pharmacology", published
by Jaypee brothers, New Delhi, 7th edition, page no. 511.
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