Wednesday, March 21, 2018

Hydroxyurea

Mechanism of action of Hydroxyurea-

Hydroxyurea  is well absorbed after oral administration, converted to a free radical nitroxide in vivo, and transported by diffusion into cells where it quenches the tyrosyl free radical at the active site of the M2 protein subunit of ribonucleotide reductase, inactivating the enzyme.

Reference-
Tripathi K.D “Essentials of Medical Pharmacology", published by Jaypee brothers, New Delhi, 7th edition, page no. 858,868,874.

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