Thursday, March 22, 2018

KETOTIFEN

KETOTIFEN:
MECHANISMOF ACTION-

▪ ketotifen is non-bronchodilator antiasthmatic drug which inhibits the effect of certain endogenous substances known to be inflammatory mediators and thereby exerts antiallergic activity.
▪ ketotifen inhibit the development of airway hyperreactivity associated with activation of platelets by platelet activating factor(PAF).
▪ inhibiton of PAF induced accumulation of eosinophills and platelets in the airways; influx of eosinophils into inflammantory loci; antagonism of bronchoconstriction due to leukotriens.
▪ ketotifen also possesses a powerful and sustained non competitive histamine(H1) blocking property.

                                   

REFERENCE: : Tripathi K.D., “Essentials of Medical Pharmacology”, Jaypee brothers medical publishers, Seventh edition, New Delhi, page no.229.

1 comment:

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