Mechanism of action
Econazole interacts with 14-α demethylase, a cytochrome P-450
enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential
component of the fungal cell membrane, inhibition of its synthesis results in increased
cellular permeability causing leakage of cellular contents. Econazole may also inhibit
endogenous respiration, interact with membrane phospholipids, inhibit the transformation
of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or
phospholipid biosynthesis.
Reference: Tripathi
K.D., "Essentials of medical pharmacology", Jaypee brothers medical
publishers, Seventh edition, New Delhi, page no. 105,108.
No comments:
Post a Comment