Sunday, March 18, 2018

paromomycin-Mechanism of action

Mechanism of action of paramomycin:-   Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.


Reference:-
Tripathi k.d.,"Essentials of Pharmacology",published by jaypee brother publication ,new dehli,seventh edition,p.no:-743

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