Sunday, March 18, 2018

Ecothiophate


Mechanism of action
Echothiophate Iodide is a long-acting cholinesterase inhibitor for topical use which enhances the effect of endogenously liberated acetylcholine in iris, ciliary muscle, and other parasympathetically innervated structures of the eye. Echothiophate iodide binds irreversibly to cholinesterase, and is long acting due to the slow rate of hydrolysis by cholinesterase. It causes miosis, increase in facility of outflow of aqueous humor, fall in intraocular pressure, and potentiation of accommodation.




Reference: Tripathi K.D., "Essentials of medical pharmacology", Jaypee brothers medical publishers, Seventh edition, New Delhi, page no. 105, 108.

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