Mechanism of action
Echothiophate Iodide is a long-acting
cholinesterase inhibitor for topical use which enhances the effect of endogenously
liberated acetylcholine in iris, ciliary muscle, and other parasympathetically innervated
structures of the eye. Echothiophate iodide binds irreversibly to cholinesterase,
and is long acting due to the slow rate of hydrolysis by cholinesterase. It causes
miosis, increase in facility of outflow of aqueous humor, fall in intraocular pressure,
and potentiation of accommodation.
Reference: Tripathi
K.D., "Essentials of medical pharmacology", Jaypee brothers medical
publishers, Seventh edition, New Delhi, page no. 105, 108.
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