Mechanism
of action
Dihydroergitoxine acts as an
dopaminergic and serotonergic agonist and alpha-adrenoceptor antagonist. It
acts centrally decreasing vascular tone and slowing the heart rate, and acts
peripherally to block aplha-receptors. One other possible mechanism is the
effect of ergoloid mesylates on neuronal cell metabolism,resulting in improved
oxygen uptake and cerebral metabolism, thereby normalising depressed
neurotransmitter levels.
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