Mechanism
of action
Duloxetine inhibits the reuptake of serotonin and norepinephrine (NE) in the central nervous system. Duloxetine increases dopamine (DA) specifically in the prefrontal cortex, where there are few DA reuptake pumps by the inhibition of NE reuptake pumps (NET) which mediates the reuptake of DA and NE.
Duloxetine inhibits the reuptake of serotonin and norepinephrine (NE) in the central nervous system. Duloxetine increases dopamine (DA) specifically in the prefrontal cortex, where there are few DA reuptake pumps by the inhibition of NE reuptake pumps (NET) which mediates the reuptake of DA and NE.
·
duloxetine has no significant
affinity for dopaminergic, cholinergic, histaminergic, opioid, glutamate, and
GABA reuptake transporters and can therefore be considered to be a selective
reuptake inhibitor at the 5-HT and NE transporters.
·
analgesic properties of duloxetine in the
treatment of diabetic neuropathy and central pain syndromes such as
fibromyalgia are believed to be due to sodium ion channel blockade.
Reference: Tripathi
K.D., "Essentials of medical pharmacology", Jaypee brothers medical
publishers, Seventh edition, New Delhi, page no. 458,462.
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