Mechanism of action
Tigecycline is broad-spectrum antibiotic
that acts as a protein synthesis inhibitor. It exhibits bacteriostatic
activity by binding to the 30S ribosomal subunit
of bacteria and thereby blocking the interaction of aminoacyl-tRNA
with the A site of the ribosome.[17]
In addition, tigecycline has demonstrated bactericidal activity against isolates
of S. pneumoniae
and L. pneumophila.[12]
It is a third generation tetracycline
derivative within a class called glycylcyclines
which carry a N,N-dimethyglycylamido (DMG) moiety attached to the 9-position of tetracycline
ring D.[18] With structural modifications as a 9-DMG derivative of minocycline, tigecycline
has been found to improve minimal inhibitory concentrations against Gram-negative
and Gram-positive organisms, when compared to tetracyclines.
Reference: Tripathi
K.D., "Essentials of medical pharmacology", Jaypee brothers medical
publishers, Seventh edition, New Delhi, page no. 733, 738..
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