Mechanism of action of pentobarbital:- Pentobarbital binds at a distinct binding
site associated with a Cl- ionopore at the GABAA receptor, increasing the
duration of time for which the Cl- ionopore is open. The post-synaptic
inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of
these effects are associated with marked decreases in GABA-sensitive neuronal
calcium conductance (gCa). The net result of barbiturate action is acute
potentiation of inhibitory GABAergic tone. Barbiturates also act through potent
(if less well characterized) and direct inhibition of excitatory AMPA-type
glutamate receptors, resulting in a profound suppression of glutamatergic
neurotransmission.
Reference:-
Tripathi k.d.,"Essentials of Pharmacology",published by
jaypee brother publication ,new dehli,seventh edition,p.no:-398
No comments:
Post a Comment