Mechanism
of Action
Drug
and its active metabolite is selective peripheral histamine H1 receptor antagonist.
Thus it prevents the attachment of histamine on receptors and its activation (Activation
of receptors of histamine on various tissues produce various allergic symptoms e.g.
Runny nose).Ebastine also has a specific inhibitory effect on Th2-type cytokine
production and inhibit T cell migration and pro-inflammatory cytokine production
by T cells and macrophages.
Reference: Tripathi
K.D., "Essentials of medical pharmacology", Jaypee brothers medical
publishers, Seventh edition, New Delhi, page no.167,528
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