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Thursday, March 22, 2018

NEOSTIGMINE MECHANISM OF ACTION

 NEOSTIGMINE
MECHANISM OF ACTION:

  •   neostigmine indirectly stimulates both nicotinic and muscarinic receptors by interfering with the breakdown of acetylcholine.
  •  neostigmine binds to the anionic and esteric site of cholinesterase and block the active site of acetylcholinsteraseso the enzyme can no longer breakdown the acetylcholin molecules.
  •  this allow for the threshold to be reached so a new impulse can be triggered in the next neurone.
  •  acetylcholin can bind to the receptors and trigger a muscular contraction.
                    
  
REFERENCE: Tripathi K.D., “Essentials of Medical Pharmacology”, Jaypee brothers medical publishers, Seventh edition, New Delhi, page no.107,108.
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