NEOSTIGMINE
MECHANISM OF ACTION:
MECHANISM OF ACTION:
- neostigmine indirectly stimulates both nicotinic and muscarinic receptors by interfering with the breakdown of acetylcholine.
- neostigmine binds to the anionic and esteric site of cholinesterase and block the active site of acetylcholinsteraseso the enzyme can no longer breakdown the acetylcholin molecules.
- this allow for the threshold to be reached so a new impulse can be triggered in the next neurone.
- acetylcholin can bind to the receptors and trigger a muscular contraction.
REFERENCE: Tripathi K.D.,
“Essentials of Medical Pharmacology”, Jaypee brothers medical publishers,
Seventh edition, New Delhi, page no.107,108.
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