Search This Blog

Thursday, March 22, 2018

Metronidazole


Mechanism of action
Metronidazole is a prodrug. Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. This reduced metronidazole then covalently binds to DNA, disrupt its helical structure, inhibiting bacterial nucleic acid synthesis and resulting in bacterial cell death.

Reference: Tripathi K.D., “Essentials of Medical Pharmacology”, Jaypee brothers medical publishers, Seventh edition, New Delhi, page no. 657, 658

at
Labels:

No comments:

Post a Comment

Subscribe to: Post Comments (Atom)

 

  • NIFEDIPINE
    NIFEDIPINE: MECHANISM OF ACTION- •    It’s a prototype DHP with a rapid onset of action with short duration. •    It’s a calcium channel...
  • DOXACURIUM
    Doxacurium   binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in...
  • doxycycline
    Doxycycline   inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.   Doxycycline   has bacteriostatic activity a...