Mechanism of action
·
Proposed mechanism of action includes
platelet mediated triggering of the release of excretory antigen from microfilariae
with killing of drug induced teration of prostaglandin metabolism in microfilariae
and/or in host endothelial cells. Leading to immobilization of microfilariae on
surfaces and adherence and killing by host platelet and granulocytes and
inhibition of pf microtubule polymerization.
·
The mechanism of action of
diethylcabamazine is thought to involve sensitizing the microfilariae to
phagocytosis.
·
One study showed that diethylcarbamazine
activity against bruzia malayi microfilariae is dependant on inducible nitric-oxide
synthase and the cyclooxygenase pathway.
Reference: Tripathi K.D., "Essentials of Medical pharmacology", Jaypee brothers medical publishers, Seventh edition, New Delhi, page no. 850, 853.
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