Mechanism of action
· Proposed mechanism of action includes platelet mediated triggering of the release of excretory antigen from microfilariae with killing of drug induced teration of prostaglandin metabolism in microfilariae and/or in host endothelial cells. Leading to immobilization of microfilariae on surfaces and adherence and killing by host platelet and granulocytes and inhibition of pf microtubule polymerization.
· The mechanism of action of diethylcabamazine is thought to involve sensitizing the microfilariae to phagocytosis.
· One study showed that diethylcarbamazine activity against bruzia malayi microfilariae is dependant on inducible nitric-oxide synthase and the cyclooxygenase pathway.
Reference: Tripathi K.D., "Essentials of Medical pharmacology", Jaypee brothers medical publishers, Seventh edition, New Delhi, page no. 850, 853.