Wednesday, March 21, 2018

Hydroxocobalamin


Mechanism of action of Hydroxocobalamin

The action of Cyanokit in the treatment of cyanide poisoning is based on its ability to bind cyanide ions. Each hydroxocobalamin molecule can bind one cyanide ion by substituting it for the hydroxo ligand linked to the trivalent cobalt ion, to form cyanocobalamin, which is then excreted in the urine.

Reference :- 
Tripathi K.D,"Essentials of Medical Pharmacology", published by Jaypee brothers, New Delhi, 7th edition, page no. 605-608.

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