Mechanism of action of paromomycin and Spectinomycin:-
Paromomycin and spectinomycin inhibits protein synthesis by
binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal
RNA complexes which are composed of 2 subunits, a large subunit (50s) and small
(30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of
this ribosomal structure. They binds to the A site, which causes
defective polypeptide chains to be produced. Continuous production of defective
proteins eventually leads to bacterial death.
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